The problem of two domain names sharing the same server

  node.js, question

The server script uses node.js. The problem now is that one of my domain names uses HyperText Transport Protocol, which can be accessed directly. Now I have the second domain name and use 8080 port. External access can only be accessed after the domain name: 8080. This is too troublesome. Is there any way to directly access two domain names without adding port number. 80 is only one.

Nginx is used to distinguish.